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Mitochondrial structure, electron transport chain, proton pumping

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Life Science
LIFE 210
Paul Laybourn

3 October Introduction Cells produce ATP two ways Substrate level phosphorylation (steps 6 & 7 of glycolysis) Oxidative phosphorylation (ETC & ATP synthase) Oxidation of nutrients through glycolysis, TCA cycle, etc. Produces NADH and FADH 2 Does not use molecular O 2 - NADH and FADH pass 2 s downhill to O through2ETC Through series of e acceptors/donors Uses molecular O 2 - + Downhill e flow drives H pumping out of mitochondrial matrix Mitochondrial Structure Intermembrane space pH 7 Outer membrane – porous Inner membrane Impermeable ETC & ATP synthase Matrix TCA cycle enzymes pH 8 Cytoplasm pH 7 Chemical Components of the ETC e carriers Go through redox cycles NAD + ↔ NADH (2 e , 1 H ) + FAD ↔ FADH (2 e, 2 H )- + 2 FMN ↔ FMNH (2 e, 2 H ) - + - + CoQ ↔ CoQH (2 e, 2 H ) Fe ↔ Fe (1 e)2 - +2 + - Cu ↔ Cu (1 e) The Electron Transport Chain Complexes Overview of the Electron Transport Chain 4 complexes Electrons start from NADH, succinate from TCA cycle Feed into ubiquinone pool Proton pumping in complexes I, between II and III, and IV Electrons from III pass to cytochrome C, then complex IV, then to O 2 Complex I: NADH-CoQ Reductase - Passes e from NADH to Coenzyme Q
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