LIFE 210 Lecture Notes - Atp Synthase, Citric Acid Cycle, Oxidative Phosphorylation
Document Summary
Substrate level phosphorylation (steps 6 & 7 of glycolysis) Oxidation of nutrients through glycolysis, tca cycle, etc. Nadh and fadh2 pass e-s downhill to o2 through etc. Downhill e- flow drives h+ pumping out of mitochondrial matrix. Electrons start from nadh, succinate from tca cycle. Proton pumping in complexes i, between ii and iii, and iv. Electrons from iii pass to cytochrome c, then complex iv, then to o2. Passes through intermediate (fmn, flavine mononucleotide fmnh2) iron sulfur complex. Coenzyme q picks up protons from matrix coqh2. Passes e- to coq picks up protons coqh2. Coqh2 from complex i & ii and coq cycle feeds e- into cytochrome b2 (or bl) Complex iv: cytochrome c oxidase e- from cyt c. Pass to o2, picks up protons from matrix h2o. Complex iv transfers 4 e- to o2 sequentially. Coupling of energy drives additional change puts binding site on outside.