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United States (324,358)
Life Science (261)
LIFE 210 (38)

Membrane proteins, detergents, glycoslyation

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Life Science
LIFE 210
Paul Laybourn

19 September Introduction Lipid bilayer Provides structure Acts as a permeability layer Membrane proteins – provide functions Transport Signaling Cell recognition Photosynthesis, electron transport chain, oxidative phosphorylation Membrane protein content varies Three Classes of Membrane Proteins Classified by how the protein associates with the membrane Lipid anchored Peripheral Integral Lipid Anchored Proteins Intracellular side Stuck on fatty acids (N-terminal-NH o2 ser/thr –OH) or prenyl group (cys –SH) Extracellular side Stuck on membrane lipids (C-terminal –COO ) - Peripheral Membrane Proteins Bind anchored and integral membrane proteins and membrane lipids Bind through non-covalent bonds Can be removed by high salt washes Integral Membrane Proteins Inserted into lipid bilayer hydrophobic environment Transmembrane proteins Span lipid bilayer Single pass transmembrane protein Extracellular side Disulfide bonds, sugars attached Hydrophobic α-helix (~20 a.a.) H-bonds between backbone
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