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LIFE 210 (38)

Notch, Delta, Wnt/beta-catenin, Hedgehog, TNF-alpha/NFkappaB

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Life Science
LIFE 210
Paul Laybourn

4 November Signaling between adjacent cells via Notch and Delta regulates cell fate choices Latent regulation: cells signal their neighbors to become a certain cell type Notch and Delta are single transmembrane proteins Binding is modulated by Notch glycosylation Processing and activation of Notch by proteolytic cleavage Notch undergoes 3 successive changes, the last 2 triggered by Delta binding γ-secretase mediates the last cleavage The cytosolic fragment translocates to the nucleus → activation of transcription Once activated it cannot be used again The Wnt/β-catenin signaling pathway Wnts are secreted proteins that act as local mediators involved in development No Wnt signaling → β-catenin is degraded in proteasomes Binding of Wnt to its cell surface receptor → no β-catenin degradation → it migrates to the nucleus, and
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