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LIFE 210 (38)

Cytoskeleton, polymer formation, microtubules, actin

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Life Science
LIFE 210
Paul Laybourn

7 November The cytoskeleton Actin filaments, microtubules, and intermediate filaments Variety of functions, shape and structure, cell movement, cell division, intracellular transport, muscle contraction, axon extension, etc. Accessory proteins Cytoskeleton rearrangement can occur rapidly Example of a neutrophil in pursuit of bacteria They advance by extending protrusions at the leading edge filled with actin filaments The cytoskeleton can form stable structures Polarized epithelial cells: actin bundles stabilize the microvilli that increases cell surface Each type of cytoskeletal filament is constructed from smaller protein subunits Small subunits can diffuse rapidly within the cytoplasm whereas assembled filaments cannot. Filaments can be rapidly disassembled at one site and reassembled in another site far away. Filaments formed by multiple protofilaments have advantages Protofilaments typically twist around each other forming lateral interactions. Provides resistance to breakage, while the ends are dynamic. Nucleation is the rate-limiting step in p
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