Class Notes (837,484)
United States (325,077)
Life Science (261)
LIFE 210 (38)
Lecture

Telomerase, telomeres

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Department
Life Science
Course
LIFE 210
Professor
Paul Laybourn
Semester
Fall

Description
5 December Telomerase replicates the ends of chromosomes Human telomeres ≈ 1,000 repeats of the sequence GGGTTA Needs to be replenished each time the cell divides Telomerase recognizes the tip of a telomere and extends it in 5’ – to – 3’ direction Uses RNA template that is part of the enzyme Telomere replication The 3’-DNA end of each telomere is always longer than the 5’-end. This leaves a protruding single-stranded end that loops back forming a t-loop. A t-loop at the end of a chromosome
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