LIFE 210 Lecture Notes - Keratinocyte, Immunoglobulin Light Chain, Immunoglobulin Heavy Chain

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30 Mar 2014
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Actin-based motor proteins are members of the myosin superfamily. Heavy chain: globular head domain + long coiled-coil that mediates dimerization (tail) The tail bundles itself with the tails of other myosin molecules (muscle myosin) Myosin tail-tail interactions form large bipolar thick filaments . Contains several hundred myosin heads that bind and hydrolyze atp. Good for sliding actin filaments of opposite orientation. The myosin head alone can generate filament sliding in vitro. The motor activity is contained within the head domain. All share a similar motor domain but the tails are very diverse. One of them moves towards the minus end of the actin filament. There are two types of microtubule motor proteins; kinesins and dyneins. Major roles in cell division and organelle movement. The structural similarity of myosin and kinesin indicates a common evolutionary origin. Motor proteins generate force by coupling atp hydrolysis to conformational changes kinesin.

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