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Cell cycle control, Cdks

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Colorado State University
Life Science
LIFE 210
Paul Laybourn

30 November The cell cycle control system Connected series of biochemical switches. On/off type 3 major checkpoints The cell cycle control system depends on cyclin-dependent protein kinases (Cdks) Cyclins undergo a cycle of synthesis and degradation in each cell cycle. Cdk levels stay constant. 3 cyclins are required in all eukaryotic cells. Yeast: 1 Cdk, Vertebrate: 4 Cdks Cdk activity can be suppressed by Cdk inhibitory proteins (CKI) Help fine tune G 1S- and S-Cdks, in addition to cyclin synthesis/degradation (main mechanism) and Cdk phosphorylation The cell-cycle control system depends on cyclical proteolysis Anaphase-promoting complex or cyclosome (APC/C), an ubiquitin ligase SCF is also an ubiquitin ligase The cell-cycle control system function as a network of biochemical switches Each switch is influenced by various inhibitory mechanisms: information about environment, cell damage, incomplete cell cycle events, etc. S-Cdk initiates DNA replication once per cycle The genome must be copied only
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