Bacterial composition, biofilm discovery, function of polysaccharide layer, S-layer, mycolic acid layer, diagnosis for TB, pili/fimbriae, sex pili, flagella, motility, chemotaxis

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Microbio, Immun, Pathology
MIP 300
Erica Suchman

1 FebruaryComponents external to the cell wallCapsulewell organized layer of polysaccharides sugars not easily removedSlime layerless well organized layer of polysaccharide easily removedBiofilm a collection of bacteria growing togetherProtected by and attached by layers of polysaccharideForm on teeth rocks other surfacesCan be medically importantBiofilm discoveryMan with pacemaker developed fever elevated white blood cellsPut on antibioticscuredInfection a few months laterantibioticscuredCycleNew pacemaker old had biofilmAs biofilm grows bacteria leaveIn biofilm genes to form polysaccharide layer and antibiotic resistance genes on flagella genes offAfter leaving polysaccharide genes turned off antibiotic resistance off flagella genes onWhen on antibiotics free bacteria are killed offSeptic bloodImplant must be surgically removedQuorem sensingbacteria communicating which genes to turn onoffFunction of polysaccharide layer
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