Exotoxins, endotoxins, innate immune response, fever

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Microbio, Immun, Pathology
MIP 300
Erica Suchman

15 FebruaryExotoxinsProteins made by gramand gram 4 typesNeurotoxinsaffect nervous systemEg botulisminhibits stimulatory neurotransmitter release from nerves no nerve impulses flaccid paralysisTetanusinhibits inhibitory neurotransmitter release from nerves constant nerve impulses spastic paralysisEnterotoxinsaffect GI tractEg cholera E coli stop HO uptake in intestines diarrhea2Cytotoxinsaffect cellular functionsEg diphtheria Shigella food borne illness Anthrax inhibit protein synthesisSuperantigensoverstimulate the immune system cause similar response to endotoxinsEg Staphylococcus aureus TSST1 toxic shock syndrome toxin 1ExotoxinsGenes chromosomal plasmids phageE coliplasmidDiphtherialysogenic phage integrated into the genomeShigella dysenteriaechromosomalVery toxicCause an immune responsemake antibodies specific for the toxin called antitoxinsToxins used to make vaccinesheat inactivated toxins toxoids after symptomsEg tetanusCan inject people with antitoxins past exposureantiserum or antitoxin
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