MIP 300 Lecture Notes - Coronavirus, Rhinovirus, Coinfection
28 Jun 2014
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Persistent or chronic last many years, e. g. hepatitis b, mono. Latent virus stops reproducing for periods of time but can be reactivated, e. g. all herpes viruses, hsv i & ii, chicken pox, etc. Slow viruses take many years to get sick, actually not viruses, new organisms: prions. Found in humans, cats, cows, goats, sheep, deer, elk, ferrets, mink (probably all mammals) Scrapie (sheep, goats) known for 250 years. Mad cow disease 1st case 1986, 95% in uk nvcjd (new variant creutzfeld-jacob disease, humans) 1st case 1996. Chronic wasting disease (deer and elk) known since 1967. Prions are thought to cause disease when they enter the brain and change the shape of naturally occurring prion proteins found in all mammals" brains. Infection with certain viruses correlates with an increased risk of developing specific cancers (in asia) Ebv: burkett"s lymphoma (in africa, co-infection with malaria), nasopharyngeal. Htlv i & ii: t-cell lymphoma (adult onset in u. s. , 100% correlated)
