MIP 315A Lecture Notes - Rheumatoid Arthritis, Heart Failure, Chronic Obstructive Pulmonary Disease

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Catch-all phrase to describe lung diseases characterized by chronic airway obstruction. Can cause right-side heart failure (blood flow is restricted), peripheral edema. Enlargement of the airspace with destruction of alveolar walls. Alveolar walls destroyed surface area for gas exchange decreases. Pinkish skin and barrel-shaped chests due to overinflated lungs (since they"re trying so hard to breathe deeper) They are run by antibodies which are always present. Type iv is delayed t cell mediated. Fall out of solution, stick to vessels, trigger inflammation. Type i, ii, & iii can lead to anaphylactic shock. Type iv is delayed because it takes a while to develop enough t cells to respond. Begins as single transformed cell (requires multiple genetic changes) Tumors must be able to get into vessel and be able to grow new vessels to be malignant. Oncogenes: normally affect the rate of cell division. Tumor suppressor genes affect dna repair and rate of cell death.

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