Bone remodeling, osteoporosis, osteomalacia, osteoarthritis, cartilage, gout, skin

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Microbio, Immun, Pathology
MIP 315A
Gerald Callahan

12 AprilLecture 25 and 26 ObjectivesUnderstand the role of osteoblasts and osteoclastsKnow the epidemiology pathogenesis risk and treatments for osteoporosisUnderstand the etiology and pathogenesis of osteomalacia ricketsUnderstand the pathogenesis of osteoarthritisUnderstand the etiology and pathogenesis of goutOsteoporosis Epidemiology28 mil cases in the USBone RemodelingActivation Preosteoclasts mature into active osteoclastsResorption Osteoclasts digest mineral matrix old boneReversal End of resorptionVitamin D3 and parathyroid hormone play a big role in preosteoblastsactivation of osteoclastsEffects of Parathyroid HormoneUltimately activates osteoclasts but only in the presence of osteoblastsOsteoporosisweak bones due to breaking down faster than rebuildingSpine column gets compressedBreaks in bones cant support weightPrimarily in elderly especially womenRisk factorsOverproduction of parathyroid hormone
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