Breast cancer, hematopoiesis, cell functions, iron deficiency anemia

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Microbio, Immun, Pathology
MIP 315A
Gerald Callahan

24 FebruaryWomen are at higher risk of breast cancer the longer they are exposed to estrogenMenstruating earlier in lifeMenopause later in lifeHormone replacement therapyAlso obesity lack of physical activity alcohol use diet high in saturated fatsGenetic FactorsAbout 5 to 10 of breast cancers occur in women with an inherited susceptibility to cancerThe majority of these are women with hereditary breast and ovarian cancer syndrome which is explained by deleterious mutations in the BRCA1 and BRCA2 genesIn approximately 25 of women with breast cancer theres a genetic alteration in the HER2 gene that produces an increased amount of the growth factor receptor protein on the tumor cell surfaceThe TP53 gene p53 is found altered in breast carcinomas in approximately 2040 of all casesMost breast cancers are ductal carcinomasUsually die due to metastasesBRCA12DNA repairForm a complex interact w p53Objectives Lecture 11Understand the process of hematopoiesis and its cellular productsUnderstand the pathogenesis of irondeficiency anemiaKnow the symptoms and pathogenesis of mononucleosisUnderstand the differences between Hodgkins and nonHodgkins lymphomas
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