MIP 342 Lecture Notes - Plasma Cell, Degranulation, Immunoglobulin Class Switching
3 Jul 2014
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Document Summary
B cell and t cell become activated by associated epitopes (not necessarily the same) Linked recognition can be exploited in vaccine development. For example: hib vaccine haemophilus influenza type b bacteria. B cell binds virus through viral coat protein virus particle is internalized and degraded. Peptides from internal proteins of the virus are presented to the t cell, which activates the b cell activated b cell produces antibody against viral coat protein. B cells from circulation enter ln/spleen via hev. Encounter antigen at tcell-bcell border and get activated by signal 1 (bcr+antigen) and signal 2 (th) Migrate to a primary focus (not a follicle) in medullary sinus and make early igm which enters circulation. Migrate to primary follicles which grow into secondary follicles with germinal centers. Two genetic alterations occur affinity maturation through somatic hypermutation, class (isotype) switching. The activated b cells (and t helpers) hang out in the primary foci proliferating for a few days and make early antibody.
