Hypersensitivity reactions, allergy development, Gell & Coombs classification, serum transfer, type I hypersensitivity, food allergy vs. food intolerance, airborne allergens, dust mites, mast cells, eosinophils, measuring asthmatic response

10 Pages

Microbio, Immun, Pathology
Course Code
MIP 342
Alan Schenkel

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1 MayThe big picture hypersensitivity reactionsHypersensitivityExaggerated immune response to innocuous antigens that can cause damage to the individualAllergyA hypersensitivity reaction that can include hay fever asthma serum sickness systemic anaphylaxis or contact dermatitisAtopyHereditary predisposition to develop immediate hypersensitivity to common environmental antigens allergens atopinsRequires time for sensitizationAntigenspecificImmediate hypersensitivityOccurs within seconds to hoursAntibody mediated passive transfer with serumDelayed hypersensitivityOccurs with 2448 hours of exposureCellmediated hypersensitivityWhy do allergies developHygiene hypothesis in generalGenetically susceptible children with low exposure to infectious agents during childhood tend to develop T2 Ab responsivenessHExposure to some infectious agents during childhood drives the immune response toward T1 CMI responsivenessHImportantly lack of exposure to infectious agents fails to generate a T response IL10 regTGF maybe IL13allergic disease
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