MIP 342 Lecture Notes - Stromal Cell-Derived Factor 1, Immunoglobulin D, Mucosa-Associated Lymphoid Tissue

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lemondog142

8 Jul 2014

School

CSU

Department

Microbio, Immun, Pathology

Course

MIP 342

Professor

Alan Schenkel

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Document Summary

Hematopoiesis: formation and development of red and white blood cells from stem cells. Progenitor b cell ig-gene rearrangement, selection mature b cell. Na ve b cell without ag cell death (~90%) Na ve b cell with ag (~10%) and th cell activated b cell affinity maturation (memory b cell) or class switching (plasma cell secreted ab) Stem cell (clp) dhjh pro-b cell (ig- / , cd19) vhdhjh pre-b cell (pre-bcr) Vljl immature b cell (igm) mature b cell (igd, ready to encounter antigen) Stromal stem cells in general interact with hematopoietic stem cells, giving them signals they need to differentiate into lymphocyte progenitors. 2 roles for stromal cells in b cell development. Express adhesion molecules that keep the progenitor cells close for direct contact. After a successful rearrangement, vdjh is immediately transcribed. Il-7 receptor expression ( transcription factors rag 1 & 2 hc gene rearrangement) Important adhesion molecules and signaling events in the progression of b cell development.

Related Questions

14. An enhancer would be used for which of the following purposes
[A] Constructing a gene library
[B] Constructing an expression vector

[C] Doing a restriction digestion
[D] Attempting to "silence" a gene
[E] Constructing a recombinant plasmid

16. For gene therapy to be most effective, genes should be inserted in _______ cells
[A] white blood
[B] red blood

[C] stem
[D] All of the above

Which of the following is not a step in therapeutic cloning
[A] Eggs are taken from the recipient.
[B] A cell is removed from the recipient.

[C] The egg is stimulated to divide.
[D] Embryonic stem cells form.
[E] Stem cells differentiate into the desired cell types.

28. If a researcher were trying to entice a cell to become a neuron, the best candidate cell to start with would be a(an)
[A] pluripotent cell.
[B] adult stem cell.
[C] totipotent cell.
[D] cell from the bone marrow.

_______Column A___________________ ___________________Column B_____________________

_____ Glial Cells 1. Can be used to treat follicular B-cell lymphoma; Antibody to Fab Region

___ Helper T-Cells 2. Interspersed among columnar ciliated epithelial cells; contain macrophages

____ Avidin 3. Primary lymphoid organ

____ CD20 on B-cell leukemia 4. Ricin replacing Fc region in an anti-cancer antibody

____ Myeloid Series Cell 5. co-stimulatory molecule on APC. Binds to CD28

___ CD34 6. Can bind circulating leucocytes to endothelial linings

___ M-Cells and MALT 7. Coded for by Variable region genes and diversification and joining region genes

____ B7 8. Macrophage-like cell in the brain

____ Stromal cell 9. Isotype activating basophils and mast cells

____ Thymus 10. Macrophages in the brain

__ Erythropoetin 11. Supporting tissue for example in bone marrow

___ Heavy chain Fab Regions 12. Uses mouse CDRâs and human Fc

___ Immunotoxin 13. Hematopoietic Stem Cell Marker

____ Autologous 14. Use CD4 co-receptors and IL1 receptors to interact with activated macrophages

____ Megacaryocytes and platelets 15. Secondary lymphoid organ

____ CAM 16. Stimulates Red Blood Cell production

___ Myeloma Cell 17. From the patient her/him self

__ Humanized mouse monoclonal antibody 18. Target for Rituxin

____ Anti-idiotype antibody 19. Neutrophil

____ Cervical lymph node 20. Control blood clotting

___ Cytokines and chemokines 21. Getting out of the blood stream

____ extravasation 22. Dendritic cells in the skin

____ Langerhans cells 23. Is immortal

_____ IgE 24. Has high affinity for biotin

____ Osteoclasts 25. Signal molecules released from granules

byzantiumimpala567

1. Hemoglobin is the molecule that floats around in blood andcarries oxygen molecules to the tissues in your body.

True or false: Oxygen binds to the iron in the hemoglobinmolecule.

Select one:

True

False

2. Hemolytic disease of the newborn can happen during a woman'sfirst pregnancy where the mother is Rh- and the fetus is Rh+.

Select one:

True

False

3. Leukemia is cancer of the white blood cell. It is the resultof an abnormal white blood cell multiplying uncontrollably. Why isit so letal? Because it takes over the red bone marrow and doesn'tallow normal red blood cells, white blood cells and platelets toform.

True or false:

Without enough red blood cells, you can't bring oxygen to thetissues in your body.

Without enough platelets, you won't be able to form clots, forinstance, to stop you from bleeding when you get a cut.

Without enough normal white blood cells, you cannot fightinfections properly.

Select one:

True

False

4. The neutrophil is the first white blood cell to arrive at thesite of an infection.

Select one:

True

False

5. Blood clots serve to stop a person from bleeding, forinstance, when they get a cut (a blood vessel is broken open). Whena blood clot forms in an unbroken blood vessel, it is called anembolus; when the embolus breaks free from the wall of that bloodvessel, it is called a thrombus.

Select one:

True

False

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MIP 342 Lecture Notes - Stromal Cell-Derived Factor 1, Immunoglobulin D, Mucosa-Associated Lymphoid Tissue

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