Autoimmune disease, mechanisms of tolerance, loss of tolerance, glutens and tTG, celiac disease, anti-DNA antibodies, autoantigens, neutrophil extracellular traps, anti-neutrophil antibodies

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Microbio, Immun, Pathology
MIP 342
Alan Schenkel

6 MayGenetic factorsinfection and environmental exposureimmune regulationautoimmunity9 most common autoimmune diseasesPsoriasisAutoreactive T cells against skinassociated antigensInflammation of skin with formation of scaly patches or plaquesRheumatoid arthritisAutoreactive T cells against antigens of joint synoviumJoint inflammation and destruction causing arthritisGraves diseaseAutoantibodies against the thyroidstimulatinghormone receptorHyperthyroidism overproduction of thyroid hormonesHashimotos thyroiditisAutoantibodies and autoreactive T cells against thyroid antigensDestruction of thyroid tissue leading to hypothyroidism underproduction of thyroid hormonesSystemic lupus erythematousAutoantibodies and autoreactive T cells against DNA chromatin proteins and ubiquitous ribonucleoprotein antigensGlomerulonephritis vasculitis rashSjgrens syndromeAutoantibodies and autoreactive T cells against ribonucleoprotein antigensLymphocyte infiltration of exocrine glands leading to dry eyes andor dry mouth other organs may be involved leading to systemic diseaseCrohns diseaseAutoreactive T cells against intestinal flora antigens
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