Course of infection, inflammation, activation of dendritic cells, TH17 cells, T cell differentiation

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Microbio, Immun, Pathology
MIP 342
Alan Schenkel

8 AprilThe Course of Infection Has Distinct PhasesLocal infection penetration of epitheliumlocal infection of tissueslymphatic spreadadaptive immunityProtection against infection wound healing induced antimicrobial proteins and peptides phagocytes and complement destroy invading microorganisms activation ofT cellscomplement activation dendritic cells migrate to lymph nodes phagocyte action NK cells activated cytokines and chemokines producedpathogens trapped and phagocytosed in lymphoid tissue adaptive immunity initiated by migrating dendritic cellsinfection cleared by specific antibody Tcell dependent macrophage activation and cytotoxic T cellsInnate immunity is essential for the initiation of adaptive immunityInfection has 2 important effects on innate immunity which in turn activates the adaptive immune responseDuring the earliest stages of infection the pathogen itself induces changes to the surrounding environment inflammationPathogen components activate tissue macrophagesMacrophage releases TNF IL6 IL1Vascular endothelium activation vascular permeabilityCells migrateIgGcomplement diffuse into tissueSwelling pain dilation of vessel BP blood flow blood flow rate
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