MIP 342 Lecture Notes - Intraperitoneal Injection, Immunoglobulin A, Mast Cell
11 Jul 2014
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Document Summary
Local infection, penetration of epithelium local infection of tissues lymphatic spread. Complement activation; dendritic cells migrate to lymph nodes; phagocyte action; nk cells activated; cytokines and chemokines produced pathogens trapped and phagocytosed in lymphoid tissue; adaptive immunity initiated by migrating dendritic cells. Infection cleared by specific antibody, t-cell dependent macrophage activation and cytotoxic t cells. Innate immunity is essential for the initiation of adaptive immunity. Infection has 2 important effects on innate immunity, which in turn activates the adaptive immune response. During the earliest stages of infection, the pathogen itself induces changes to the surrounding environment: inflammation. Immature dc become activated by pamps (pathogen-associated molecular patterns) via tlrs. Cytokines present at this stage influence what type of effector a cd4 t cell differentiates into. Effector t cells re-enter circulation and home to the site of infection. Which is now putting up new adhesion molecules. Change surface molecules now needs to traffic into infected tissue, not through lymph nodes.
