T cell development, positive selection, negative selection, peripheral lymphoid organs, autoreactive mature T/B cells

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Colorado State University
Microbio, Immun, Pathology
MIP 342
Alan Schenkel

8 MarchSteps of T Cell DevelopmentDouble negativeEarly lymphoid progenitor ETP enters the thymus at the corticomedullary junctionNot committed to T cell lineage yet if picked up and put in bone marrow could become B cell NK cellNotch1 receptor on the early lymphoid progenitor receives signal Notch protein from thymic stroma to commit to the T cell lineageSignals to put up CD3A successfully produced chain protein binds to a surrogate chainThe newly formed preTCR associates with CD3 at the surfaceNow the preTCR can send a signal that halts chain rearrangement so the other chain allele shouldnt get made allelic exclusionAlso sends a signal to move to the next stepThe precursor proliferates rapidly and then stopsDouble positiveWhen proliferation stops the immature T cell expresses CD4 and CD8 at the surface and chain gene rearrangement beginsPositive SelectionDP T cells interact with thymic cortical epithelial cells in the cortexDP T cells that can recognize self MHC and self Ag will survive and drop either CD4 or CD8now CD4 or CD8 become single positiveDP T cells that dont recognize MHC on thymic cortical epithelial cells dieNegative Selection
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