Receptor generation, antibody basics, monoclonal antibodies vs. polyclonal anti-serum, antigen, protein structure, kinds of immunoglobulin

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Colorado State University
Microbio, Immun, Pathology
MIP 342
Alan Schenkel

8 FebruaryIn the classical complement cascade C4 is out of numerical order after C1q but before C2Chapter 4 What I want you to knowStructure of antibodiesHow atomic and molecular forces bind proteinsHow a T cell recognizes an antigenGeneration of Unique and Highly Specific Receptors against Foreign AntigensAntibodies Ab and the B cell receptor BCRT cell receptor TCRMajor Histocompatibility Complex MHCClass Imost cellsClass IIimmune cells onlyBig picture rearranged genes for antibodiesB cell receptorsT cell receptors generates millions of potential combinations to specifically recognize millions of foreign and self antigensInherited gene segmentsunique combination of segments becomes joined by somatic gene rearrangementchains pair to give a unique receptor for each lymphocytechains in B and T cell receptorsAntibody basics Immunoglobulin IgMonomer can bind at two sitesBinding site on antigen is called the epitopeTherefore an antibody can bind two epitope sites
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