MIP 342 Lecture Notes - Monomer, Immunoglobulin D, Antigen-Presenting Cell
Document Summary
In the classical complement cascade, c4 is out of numerical order (after c1q but before c2) Chapter 4: what i want you to know. Generation of unique and highly specific receptors against foreign antigens. Antibodies (ab) and the b cell receptor (bcr) Big picture: rearranged genes for antibodies/b cell receptors/t cell receptors generates millions of potential combinations to specifically recognize millions of foreign and self antigens. Inherited gene segments unique combination of segments becomes joined by somatic gene rearrangement chains pair to give a unique receptor for each lymphocyte chains in b and. Binding site on antigen is called the epitope. Therefore an antibody can bind two epitope sites. Monoclonal antibodies come from a single b cell clone, have a single epitope. Mouse, rat, hamster spleen cell fuses to immortal cells, forms a hybridoma. Second time used mouse cells recognized as non-self and destroyed. A lot of antibodies that recognize several epitopes including completely unrelated antigens, therefore polyclonal.