Effector T cell locating, memory B cells, memory T cells, flow cytometry, scattered light, fluorescence

4 Pages
Unlock Document

Colorado State University
Microbio, Immun, Pathology
MIP 342
Alan Schenkel

10 AprilHow do effector T cells home to infected tissue once they leave the peripheral lymphoid tissueEffector T cells change their surface moleculesCD44 is expressed on activated T cellsTraffic to sites of inflammationBinds to hyaluronic acid expressed on most endothelialepithelial cells more highly expressed during inflammationThe cell surface proteins expressed by effector cells help us to distinguish them from nave T cells and even from memory T cellsIsoforms of CD45CD45RA nave CD45RO effectorDifferential splicing of CD45 mRNA RO is smallerNave T cell CCR7 CD62LEffector T cell CD44 LFA1 VLA4Memory Immune Responsessecondary responses tertiary etcBasis of immunization 200 yrsNot dependent on repeated exposure to infectionDuration of memory cellsMemory B cellsWhen memory B cells get Signal 1 from antigen and Signal 2 from T maybe not Hnecessary theyProliferate at the B cell zoneT cell zone border in lymph nodespleenMigrate to a germinal center and undergo further somatic hypermutation and isotype switchingAffinity of IgG antibodies increases with each exposure to antigen
More Less

Related notes for MIP 342

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.