Immune response therapies, immunosuppressive drugs, cytotoxic drugs, humanized antibodies

5 Pages
Unlock Document

Microbio, Immun, Pathology
MIP 342
Alan Schenkel

10 MayThe big pictureEasier to block or attenuate primary immune response than to suppress an established responseVery time dependentTransplantationWelldefined antigensKnowledge of when immunosuppression will be necessaryRelatively effective therapiesAutoimmune diseasePoorlydefined antigensCant predict when it will happenLess effective therapiesTherapies to manipulate immune responsesIn order of increasing specificitySteroids like most immunosuppressive drugs act nonspecifically affect almost all body systemsCytotoxic drugsAffect rapidly dividing cells in S phaseImmune cells proliferate in synchrony after stimulationGiven immediately after the transplant to kill highof a relatively small number of Agspecific cellsBiologicals interfere with T cell signalingSoluble cytokine receptorsAnticytokine therapiesAntibodies inhibiting T and B cell functionAntigenspecific therapies highly specific
More Less

Related notes for MIP 342

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.