B cell maturation, somatic hypermutation, class switching
B cell maturation, somatic hypermutation, class switching

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School
Colorado State University
Department
Microbio, Immun, Pathology
Course
MIP 342
Professor
Alan Schenkel
Semester
Spring

Description
15 FebruaryNucleotide additions by TdT must be inframe or premature termination and death of cell resultsMore gene changes to B cellsSomatic hypermutation by AICDGene conversion rare long slow process except in birds part of psuedogene is spliced inClass switchIsotypic differencesdifferent classAllotypic differencesallele differencesIdiotypic differencesrecognize different epitopesSomatic hypermutation occurs via activation induced cytidine deaminase AICD and friendsDNA in variable region or in switch regiontranscription produces local singlestranded DNAin B cells AID attacks cytidine in s
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