Receptor clustering, typical signaling, cytokines, second messengers, transcription factors, immunoreceptor tyrosine, TCR

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Microbio, Immun, Pathology
MIP 342
Alan Schenkel

22 February T cell receptors antibody B cell receptorsT cell receptors all use VDJ recombinationMHC molecules do notChapter 7 Signaling part 2What do I want you to knowDont panicVery easy concept will be on the testKINASES HAPPENReceptorsignal transduction basicstargetLife and death via receptorsReceptors you need to knowTCR and BCRFcR complement RPAMP receptors Tolllike receptorsesp TLR4Cytokine receptorsMost are heterodimericTNF receptors and FAS are trimericChemokine CXCL8 receptors CXCR1 and CXCR2Adhesion molecules selectins integrins and CAMsAt the surface clustering of receptorsPhysically brings molecules close to interactphosphorylation and PIDAGTCR and BCR supramolecular adhesion complex SMACimmunological synapseLipid rafts or islands in the plasma membrane
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