MIP 342 Lecture Notes - Alkylation, Antitoxin, Rubella Virus
11 Jul 2014
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Document Summary
Hiv uses immune receptors (cd4 and cytokine) that are needed by immune system. High mutation rate of hiv; rt is sloppy". Hiv may be latent for years before causing aids. Hiv may be encountered daily by individuals at high risk. Difficult to get vaccines to protect the urogenital tract. No animal models mimic the disease in humans close enough to enhance the testing of vaccines for efficacy and safety. Controlling/stopping unwanted immune responses via drugs and antibodies. Helping weak responses or initiating primary response against pathogens by vaccines. Safe vaccine must not itself cause illness or death. Protective vaccine must protect against illness resulting from exposure from live pathogen. Gives sustained protection protection against illness must last for several years. Induces neutralizing antibody some pathogens (such as polio virus) infect cells that cannot be replaced (e. g. neurons). Neutralizing antibody is essential to prevent infection of such cells.
