TCR signaling, B-cell signaling, receptors, chemokines, apoptosis

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Microbio, Immun, Pathology
MIP 342
Alan Schenkel

25 FebruaryTCR signalingKinases happenPLC is activated by Itk and cleaves phosphatidylinositol bisphosphate PIP to yield diacylglycerol DAG and inositol trisphosphate IPIP 2332increases intracellular Ca concentration activating a phosphatase calcinerium DAG recuits protein kinase C DAG recruits RasGRP which in turn activates Rascalcineurin activates a transcription factor NFAT nuclear factor of activated T cells protein kinase C activates CARMA which leads to activation of NFB Ras activates the MAP kinase cascade which activates Fos a component of the AP1 transcription factorthe transcription factors NFB NFAT and AP1 act to induce specific gene transcription leading to cell proliferation and differentiationLATadaptor protein is phosphorylated phosphorylates G proteinMAP kinase cascadeTCR and CD28PLC2IPCaNFAT3DAGRasGRPAP1DAGPKCNFBWith these transcription factors IL2 gene is producedBcell signaling is similar to CD4CD8CD3 CD21CD19CD81 also help propagate a signal when antigen binds to the BCRKinases happenPLC cleaves phosphatidylinositol bisphosphate PIP to yield 2diacylglycerol DAG and inositol trisphosphate IP32DAG and Ca activate protein kinase Cprotein kinase C activates a transcription factor NFBSmall G proteins activate MAP kinase cascadesthe Rasinduced kinase cascade induces and activates Fos a component of the AP1 transcription factor
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