Antibodies, MHC, pathogen classes, secondary immune response, immune organs, lymphatic system, thymus, lymph node, spleen, MALT, SALT

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Colorado State University
Microbio, Immun, Pathology
MIP 342
Alan Schenkel

28 JanuaryLag phase between exposure and response710 daysB cells make antibodiesBCR T cells use the TCR conserved structures for antigen recognitionB cells have B cell receptorantibody attached to cell membraneVariable regionantigenbinding siteConstant regioneffector functionSpecific antibodybacterial toxinsforms antigenantibody complex neutralizationmacrophage recognizes antigenantibody complex ingestionSpecific antibodybacteria in extracellular spaceopsonizationingestion by macrophageSpecific antibodybacteria in plasmacomplement activationlysis and ingestionThe epitopes recognized by Tcell receptors are often buriedthe antigen must first be broken down into peptide fragmentsthe epitope peptide binds to a self molecule an MHC moleculethe Tcell receptor binds to a complex of MHC molecule and epitope peptideAntigen Presentation of viral or bacterial peptides on Major Histocompatibility Complex molecules MHCAll cells have MHC I in case of viral or intracellular infectionRecognized by CD8 cytotoxic cellsOnly immune cells have MHC II to communicate to CD4 helper T cells what they foundExtracellular and intracellular pathogens are recognized this wayThe immune system protects against four classes of pathogensExtracellular bacteria parasites fungiStreptococcus pneumonia causes pneumonia
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