Cancer, tumor rejection antigens, mechanisms by which tumors avoid immune recognition, monoclonal antibodies, co-stimulation, CTL responses

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Department
Microbio, Immun, Pathology
Course
MIP 342
Professor
Alan Schenkel
Semester
Spring

Description
29 AprilThe big pictureTumors formed from cancer cellsUnregulated rapid growth of host cellsOften dedifferentiatedAltered protein expressionImmune system eliminates most cancer cellsCD8 CTLs NK CD4 TcellsRecognize altered cellsurface protein expressionCancer cells can alter immune responseLow immunogenicityRecognized as selfAntigenic modulationTumorinduced immune suppressionExpress cytokinesIndoleamine23 dioxygenase IDO suppresses CTLsSeclusionEnhancing antitumor immune responseIncrease MHC I expression on cancer cellsMonoclonal antibodies Mabs targeting cancer cellsExpressing costimulatory molecules on cancer cellsB7GMCSFTryptophan analogs
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