MIP 342 Lecture : Innate immune system receptors, signaling, innate response, innate-like lymphocytes, oxidative burst, cytokines, GPCR, sepsis
11 Jul 2014
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Document Summary
What do i need to know: innate immune system receptors. Innate immunity specificity inherited in the genome, expressed by all cells of a particular type, triggers immediate response, recognizes broad classes of pathogens, interacts with a range of molecular structures of a given type. Adaptive immunity encoded in multiple gene segments, requires gene rearrangement, clonal distribution, able to discriminate between even closely related molecular structures. Bone marrow to thymus or peripheral tissues for development. Macrophages/dcs: endocytosis of antigens cytokines, antigen presentation, killing of endosomal pathogens migration to local lns. T cells, nk cells/ cells cytokines, activate killing inhibition of immune response (late) Development of memory in b and t cells. Direct interaction: apc (antigen-presenting cell, e. g. dendritic cell) and t cell. Natural killer lymphocytes hunt strange cells (infected) Gamma delta t cells (recognize lipids and other signals) not very motile. Invariant nk t cells (recognize lipids and other signals) B-1/marginal zone b cells act like macrophages.
