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MIP 300 Lecture Notes - Plasmid, Bacteriocin, Deoxyribonuclease

Microbio, Immun, Pathology
Course Code
MIP 300
Erica Suchman

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8 April
Combination of genetic material from two organisms
Prokaryotes may pick up exogenous DNA in 3 ways
Direct contact with other bacteria: conjugation
Direct uptake: transformation
Viral transfer: transduction
Fates of exogenous DNA in cell
Integration into host cell DNA
No integration into host cell DNA, independent replication, plasmids
Must have origin of replication
No integration into host cell DNA, degradation
Bacterial plasmids
Small circular pieces of DNA
Replicons: contain origins of replication independently replicating, stably inherited
Not essential to survival, may improve odds
Episomes: may exist as plasmids or integrate into host DNA (some)
Conjugative plasmids: carry genes for conjugation – pili and sex pili production (some)
Types of plasmids
Fertility (F) factors: conjugative, episomes
Resistance (R) factors: carry genes that confer resistance to antibiotics, often
Col plasmids: contain genes to produce bacteriocins – kill other bacteria
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