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MIP 300 Lecture Notes - Immunoglobulin M, Opsonin, Streptococcus

Microbio, Immun, Pathology
Course Code
MIP 300
Erica Suchman

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22 February
What’s happening during the primary response lag period?
Clonal selection
Thousands of immature B-cells
How specific ones become plasma cells and make antibodies
Clonal selection: T-cell dependent antigen activation
Phagocytic cell eats antigen – expresses antigens (with multiple epitopes) on cell
surface with MHC class II molecules
Immature TH recognizes specific epitope on antigen/MHC II complex – phagocytic cell
releases growth factors (interleukines and cytokines), TH becomes mature, activated,
Create many mature TH cells specific for the same epitope on the antigen
Immature B-cell surface IgM binds antigen – mature TH binds specific epitope on
antigen/MHC II complex on immature B-cell surface, releases growth factors that
activate B cells to mature, divide, and differentiate into plasma cells (produce antibody
specific to epitope on antigen), and memory cells which live few years to life time
T-helper cell receptor protein binding of epitope similar to antibody: lock and key binding of
correct shape
Clonal Selection
Plasma cells will produce antibodies. Antibodies will neutralize toxins, microbes, and
viruses, induce opsonization and complement fixation
Memory cells would wait for future infections with the same microorganism
TH also activate immature CTLs by producing growth factors after binding to CTLs that
have bound antigen – CTLs mature, divide, go kill virus infected cells, tumor cells,
Memory cells – live few years – life time. Wait for future infections
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