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Lecture

MIP 300 Lecture Notes - Typhoid Fever, Zoonosis, Hospital-Acquired Infection


Department
Microbio, Immun, Pathology
Course Code
MIP 300
Professor
Erica Suchman

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25 February
Epidemiology
Terminology
Sporadic disease – occurs occasionally at irregular intervals, e.g. typhoid
Endemic disease – steady frequency (often low level) in population, e.g. herpes
viruses (HSV, EBV, CMV, chickenpox), HPV (70% of sexually active women, 50%
men)
Epidemic – occurrence higher than expected, e.g. SARS
Index case – first
Outbreak – sudden occurrence higher than expected in a small group, e.g.
legionnaire’s
Pandemic – occurrence higher than expected world wide, e.g. influenza, HIV
Nosocomial infection – illnesses associated with hospitalization
CDC study – 10% of hospital patients develop (~2 – 4 million per year)
E.g. VRE – vancomycin resistant enterococcus
Zoonoses – animal disease transmitted to humans
Giardia: rodents, dogs, cats, cattle, deer
Hanta virus: deer mice (4%. White tummy. Urine/feces. Causes
pneumonia, hemorrhagic fever, 50% morality rate)
Plague: domestic and wild rodents
Rabies: dogs, cats, bats, rodents, cattle
Salmonella: birds, reptiles, mammals
Interesting fact: >80% of the ~1,300 known diseases are zoonotic, <100 are
human specific
Statistics
Morbidity rate: # individuals in population that become ill
Mortality rate: # of individuals in population who die
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