MIP 342 Lecture Notes - Antigen Presentation, B Cell, Chromosome
11 Jul 2014
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Exogenous and endogenous pathways, depending on virus location. Human hfe (iron metabolism), hla-e (recognize by nk), hla-g (prevents nk attack in placenta) Mic genes: recognized by nk cells and cells. Human hla-dm (removes clip), hla-dn , -do (negative regulator of dmi) Ancestral mhc gene undergoes gene duplication and divergence multiple mhc genes gene conversion between misaligned chromosomes during meiosis separated chromosome after meiosis. Less often: peptide-independent binding (t cell recognizes mhc molecule, not peptide) Tcr and chains are involved in recognition. >1 to 105 t cells recognize each peptide. Recognition restricted by an mhc class i or ii molecule. Not processed, secreted by bacteria or made by virus. 2 20% of t cells recognize each superantigen. Presented by almost any mhc class ii molecule. Suggests a strikingly different mechanism of antigen presentation and recognition. Staphylococcal entertoxins sea, seb, sec, sed, & see.
