MIP 342 Lecture Notes - Growth Factor, Lck, Interleukin 5
11 Jul 2014
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Document Summary
T cell receptors, antibody, b cell receptors, t cell receptors all use v(d)j recombination. Very easy concept will be on the test. Physically brings molecules close to interact phosphorylation and pi/dag. Tcr and bcr supramolecular adhesion complex (smac)/immunological synapse. Lipid rafts or islands in the plasma membrane. Clustering of receptor (dimerizes, brings kinase domains together) In one class of receptors, the kinase domain is an intrinsic part of the receptor ligand binding dimerizes the receptor, activating the kinases, which phosphorylate each other. Kinase domains can be built in or associated. In another class of receptors, a kinase is noncovalently associated with the receptor ligand binding dimerizes the receptor, activating the associated kinases, which phosphorylate each other the activated kinases phosphorylate downstream substrates. Homodimeric receptors receptors for erythropoietin and growth hormone. Il-2 receptor also has a third chain, a high-affinity subunit il-2r (cd25) Heterodimeric receptors (no common chain) receptors for il-13, ifn- , ifn- , ifn- , il-10.
