MIP 342 Lecture Notes - Polio Vaccine, Meningococcal Disease, Smallpox

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First vaccine give (can be as early as 1 moth after birth) No adverse side effects very safe vaccine. Not a problem for normally functional immune system. Increase lately attribute to parents refusing to get children vaccinated. Some infections for which effective vaccines are not yet available. Other organisms used as vectors: canarypox virus, poliovirus (attenuated), adenoviruses, salmonella (attenuated), bcg strain of mycobacterium bovis. Multiprotein structures can be constructed to mimic virus particles. These engineered particles lack genetic material and are not infectious but they can elicit protective immune responses in animals against challenges with infectious viruses. Protects against hpv 16, 28, 11 and 6. Synthesized viral particles of the correct shape, size and immunogenicity. Attach monoclonal ab (mab) to particulate solid matrix (inert, not immunogenic) Can mix mab and bind immunodominant epitopes for both t cells and b cells. Conditions that form vesicles bounded by a bilayer. Individual proteins orient with hydrophilic residues toward the aqueous environment.

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