MIP 342 Lecture Notes - Intracellular Parasite, Immunoglobulin G, Tumor Necrosis Factor Alpha
11 Jul 2014
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Na ve t cell: mature (out of the thymus), circulating, has not seen antigen. Effector t cell: capable of mediating an immune response, has been activated. Memory t cell: long-lived, capable of rapid and robust response to antigen upon subsequent exposure. Target cell: infected cell, tumor cell, immune cell; cell upon which effector/memory t cell is acting. Cytotoxins made mainly by ctls; perforin, granzyme, granulysin. Cytokines made by all t and b cells. Cytokines can act locally (on target cell) or distantly. Il-3; gm-csf (granulocyte-macrophage colony stimulating factor) released at site of inflammation, travel to bone marrow. Not as tightly controlled because cytokines act on cells expressing cytokine receptors and class ii mhc. Tnf- and lt- bind to tnfr-i (has death domain) on target cell trigger apoptosis. Fasl (lots on ctls) binds to fas (also on t cells, has death domain) apoptosis, clearing of t cells once infection is controlled.
