MIP 342 Lecture Notes - Cell Adhesion Molecule, Regulatory T Cell, Granulocyte Macrophage Colony-Stimulating Factor
11 Jul 2014
School
Department
Course
Professor
Document Summary
Immunize mouse with irradiated tumor cells inject viable cells of the same tumor response to unique tumor rejection antigens eliminates tumor. Immunize mouse with irradiated tumor cells inject viable cells of a different tumor response to irradiated tumor will not eliminate unrelated tumors of a different cell type. Tumor antigens taken up and presented by apcs in absence of co-stimulation tolerize t cells. Antibody against tumor cell-surface antigens can induce endocytosis and degradation of the antigen, immune selection of antigen-loss variants. Factors (e. g. tgf- , il-10, ido) secreted by tumor cells inhibit t cells directly. Factors secreted by tumor cells create a physical barrier to the immune system. Tumor rejection antigen: protein antigen expressed by tumor, recognized by immune system and results in immune response to tumor. Monoclonal antibodies against tumor antigens, alone or linked to toxins, can control tumor growth.
