SOCR 330 Lecture Notes - Sickle-Cell Disease, Overdominance, Malaria
Document Summary
Predominant in quarter horse bloodlines due to line breeding. Affected animals almost all descended from one sire impressive (1968 1995) As of 2006 over 100,000 registered quarter horses, paints and appaloosas worldwide have impressive somewhere in pedigree. Principal force altering allele frequencies in large populations. Selection operates against very high and very low birth weights in humans. Fitness measures contribution of individual genotype to the next generation. Genotype in a population with greatest reproductive success assigned a relative fitness of rf = 1. Less successful genotypes assigned proportionally lower rf values. S measures intensity of selection against a genotype. Effect of selection against a recessive allele can be calculated as q1 = q (1 sq)/1 sq2. Where: q = starting frequency of recessive allele under selection q1 = new selection of recessive allele after one generation s = selection coefficient. Farmer brown decides to poison the mice in his barn.
