ABO blood groups, epistasis

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Soil + Crop Sciences
SOCR 330
Sarah Ward

16 September Multiple Alleles at a Locus Three alleles control ABO blood groups in humans: I and I are codominant i is recessive Molecular Basis of ABO Blood Groups ABO antigens are carbohydrates on surface of red blood cells derived from precursor H molecule I allele codes for transferase enzyme that adds N-acetylgalactosamine to H precursor A → I antigen B B I allele codes for different form of transferase so adds galactose to H precursor → I antigen I codes for inactive form of transferase so H precursor unmodified (no antigens) Rare “Bombay phenotype” has abnormal form of H so no sugar can be added Bombay phenotype is type O regardless of genotype ABO Blood Group Question John has blood group AB and his wife Mary has blood group O. Their baby Sam also has blood group O, which Mary claims he must have inherited from her. John suspects, however, that Mary has been
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