SOCR 330 Lecture Notes - Pyrimidine, Ribose, Pentose
Document Summary
Used t4 bacteriophage: dna-containing virus that attacks e. coli. Worked with maurice wilkin at university of london. Use x-ray diffraction to generate images of dna molecule. Watson-crick double helix model of dna structure (b configuration) Deoxyribose-phosphate backbone with 5" end (po4) and 3" end (oh) One of four different nitrogenous bases (a, t, c, g) attached to each deoxyribose molecule. Sugar molecules and phosphate groups joined by phosphodiester bond. Dna is weak acid in solution (ph = 6. 5) Hydride ions detach from phosphate group in backbone of chain. A-dna forms under high salt concentrations or when dehydrated. 12 bases per turn, some bases in convex outer surface. Rna pentose sugar is ribose (so rna = ribonucleic acid) Rna has pyramidine base uracil instead of thymine. Retroviruses (such as hiv) insert rna into cell. Rna uses reverse transcriptase to make dna copies of viral genome.
