Hershey and Chase, Rosalind Franklin, Watson and Crick, DNA structure, RNA

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Soil + Crop Sciences
SOCR 330
Sarah Ward

30 September Hershey and Chase 1952 Used T4 bacteriophage: DNA-containing virus that attacks E. coli Rosalind Franklin (1920 – 1958) Worked with Maurice Wilkin at University of London Use X-ray diffraction to generate images of DNA molecule Realized that DNA is helix Watson-Crick Double Helix Model of DNA Structure (B Configuration) Deoxyribose-phosphate backbone with 5’ end (PO ) an4 3’ end (OH) DNA strand antiparallel One of four different nitrogenous bases (A, T, C, G) attached to each deoxyribose molecule 10 bases per complete turn of helix Base Pairing in DNA Adenine-thymine pair with DOUBLE hydrogen bond Guanine-cytosine pair with TRIPLE hydrogen bond DNA Polynucleotide Chain Sugar molecules and phosphate groups joined by phosphodiester bond DNA is weak acid in solution (pH = 6.5) Hydride ions de
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