Dosage compensation, transcriptional gene regulation

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Department
Soil + Crop Sciences
Course
SOCR 330
Professor
Sarah Ward
Semester
Fall

Description
2 November Dosage Compensation One X chromosome in every somatic cell inactivated by methylation in female mammals Lyonization Males and females have same number of active X-linked genes Tortoiseshell and Calico Cats Both X X O Calico: X chromosome inactivated early in embryonic development Tortoiseshell: X chromosome inactivated later in development Transcriptional Gene Regulation: Hormones Small molecules carried from endocrine cells to target cells Target cells contain receptor sites Most hormones effectors Possible modes of hormone action Bind directly to enhancer or promoter DNA Bind to/activate effector Inactivate receptor Change chromatin structure Gene Regulation by
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