BIOMG 1350 Lecture 23: Stem Cells
30 Nov 2016
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How do organisms maintain tissues and organs: adult stem cells generate a continuous supply of terminally differentiated cells, well studied examples: Renewal occurs continuously in the lining of the adult intestine: surface area increased by the villi along epithelial cells, crypt. Precursor cells move up and differentiate to either. Mucus secreting goblet cells or absorptive brush border cells. Intestinal epithelium cells are replaced every 3-6 days. What makes up the stem cell niche: crypt=stem cell niche. Maintains stem cells in an undifferentiated state (bmp antagonists) Promotes continued slow rate of proliferation (wnt signaling: crypt. Isemf + smc provide source of bmp antagonists: proliferative compartment. Cause cells to proliferate and differentiate in response to bmp when it is far enough for the inhibitors: differentiative compartment. The hemopoietic stem cell generates a variety of mature blood cells: the blood system is constantly renewed from stem cells that reside in the bone marrow. Therapeutic use of adult hemopoietic stem cells +16109317193: recipient.
