NS 1150 Lecture Notes - Lecture 14: Thrombosis, Atherosclerosis, Adipose Tissue
Document Summary
Review of fats: lingual lipase, in mouth, gastric lipase, in stomach to release the fatty acids. Fatty acids are the most potent stimulus for cck release: cck, bile (gall bladder, pancreatic lipase. Able to carry triglycerides through membranes: fat is stored inside of it, five kinds, chylomicron, largest of the lipoproteins. Takes chylomicron and breaks it apart (destroys it: cholesterol gets redistributed, repackages fat in vldl, sends it out to bloodstream, tissue. Sucked to adipose tissue and will wait for lipoprotein lipase: stimulated by insulin, breaks down fatty acids so they can enter fat cell. Packs fatty acids into big globule of fat: injured artery, apo-b profile exists in injured arteries, generate apo-b receptors, will stick to ldl particle, this begins the process of atherosclerosis. If artery gets injured : develops apo-b receptors, white blood cells will respond to signals coming from wall of artery.