BIO 303 Lecture Notes - Lecture 16: Y Chromosome, Cell Potency, Microtubule

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13 Mar 2017
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Instructions in genome establish the developmental fate of cells in multicellular organisms. Developmental pathways consist of sequences of various regulatory steps. Zygote is totipotent - gives rise to all body cells. Gradients of maternally-derived regulatory proteins establish polarity of the body axis and control transcriptional activation of zygotic genes. Transcriptional regulation and cell signaling mediate development in animals and plants. Many are binary - male or female. Many involve groups of cells rather than single cells. Different molecular pathways for sex determination in different groups of animals. Tdf gene on y chromosome determines maleness. Sry gene in humans encodes transcription factor (tesis- determining) Consists of highly organized rods and fibers. Asymmetry of cytoskeletal elements plays fundamental roles. In animals - germ line is set aside from soma in early development. Asymmetric distribution of cytoplasmic particles by cytoskeleton. Cells receiving particles develop into germ line. Particles anchored to actin in some organisms, to microtubules in others.

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