EBIO 1210 Lecture Notes - Lecture 12: Organelle, Monosomy, Advanced Maternal Age

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Locating genes on chromosomes: chromosomal basis for mendel"s laws (fig. 2): the random alignment of homologous pairs along the metaphase 1 plate accounts for the law of independent assortment. The chromosomes that occur as homologous pairs in all organisms of a species are called autosomes. Chromosome pairings that can vary depending on the sex of an organism are called sex chromosomes. In most vertebrates, including humans, the x and y chromosome are the sex chromosomes: sex determination (fig. : the sry (sex-determining region on the y chromosome) gene and the dax1 gene of the x chromosome. Xx are diploid for x-linked genes; on the other hand, xy males are haploid with respect to the genes present on the different x and y chromosome. Males are haploid with respect to the genes on the sex chromosomes, a condition called hemizygous. This generates a special type of inheritance called sex- linked.

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