NRSC 2100 Lecture Notes - Lecture 10: Nitric Oxide Synthase, Metabotropic Receptor, Chemical Synapse
11 Oct 2016
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Cns: need to show that the neurotransmitter has an action on a postsynaptic neuron (epsp, and ipsp have changes in the membrane potential) the chemical influences the postsynaptic neuron. I. e. glutamate is used commonly in the nervous system as a neurotransmitter. 1. glutamate, gaba, glycine--single amino acids, building blocks of proteins that are used as neurotransmitters. Major classes of neurotransmitters: small neurotransmitter molecules, amino acids: excitatory amino acidsglutamate, aspartate. They are brought in the cell by membrane proteins, the cell hardly has anything it needs to do but put in in vesicles. Many types of transporters bring glu inside cells (eaats) Vglut is responsible for packaging glutamate in vesicles. Small neurotransmitter molecules: amino acids: inhibitory amino acids: gaba. *during development however, gaba is essential for being an epsp neurotransmitter. *it is also derived directly from glutamate, it needs an enzyme called glutamic acid decarboxylase to transform it in gaba, cells that express this particular enzyme makes gaba containing neurons.
