BIOL 22000 Lecture 18: Lecture 18.2

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o Podocyte cells surrounds the capillaries and create foot processes
o In picture-d, the pores created by the gap in endothelium cells and the space
between the foot processes serve as physical filter that allow water and small
solutes to leave
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o In 100% of the volume entering the glomerulus, only 20% ends up in the
glomerulus filtrate and 80% of it go down the peritubular capillaries
o At the end, less then 1% of the volume ends up in the urine
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o The driving force of volume going from the glomerulus capillaries to Bowman’s
capsule: (3 pressure)
â–Ş Pressure in the plasma of the glomerulus
• Why is it only 55 mmHg and blood pressure is 100 mm Hg?
• Afferent arteriole can constrict, and when it gets smaller the
pressure decreases
• Efferent arteriole can also constrict, which makes the blood hard to
go out, increasing the blood pressure
• The glomerulus blood pressure is determined by afferent and
efferent arteriole
â–Ş Since protein and amino acids cannot be filtered through the glomerulus
filtration, there plasma has a higher osmolarity then the glomerulus
filtrate, this is the pi pressure
• Pi pressure does not dependent on Bowman’s capsule
• Another name for this type of pressure is called colloid osmotic
pressure
â–Ş When water leaves glomerulus, it starts to create a pressure inside the
Bowman’s capsule, and that pressure inside the Bowman’s capsule is
pushing back flow of the filtration coming from the glomerulus capillary
• This is the fluid pressure
o Kidney will try to maintain the pressure as constant as possible so there can
constant filtration going on
• Regulation of Glomerular Filtration Rate
o GFR: Intrinsic Control (Autoregulation)
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