BIO 211 Lecture 12: Week 6 class 2 ch 17
15 Feb 2017
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Document Summary
The cell-cycle control system: the cell-cycle control system triggers the major events of the cell. Cyclin-dependent protein kinases (cdks: cyclin-dependent kinases (cdks)- protein kinases that phosphorylate intracellular proteins that regulate cell cycle events. Cdk complexes: have 4 classes, g1/s cyclins- activate cdks in late g1, triggers start, s cyclins- bind to cdks after start to stimulate chromosome duplication, m-cyclins- activate cdks that start mitosis at the. Switches: proteins activate biochemical switched, cell proliferates--> activates g1-cdk---> stimulates genes to encode g1/s and s cyclins--> initiates start. Initiated in s phase when dna helicases unwinds the double helix. In late mitosis/ early g1, pre-replcative complex/ prerc forms when inactive dna helicases enter replication origin. In s phase, dna helicase is activated: origin recognition complex (orc)- binds to replication origins to aid in dna replication, cdc6 & cdt1 communicate with orc in late mitosis/ early.
