HSCI 301 Lecture Notes - Lecture 1: Low-Density Lipoprotein, Myopathy, Statin
23 Mar 2017
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Chapter 23: drugs for hyperlipidemia: for lipids, what is the general difference between chylomicrons, ldl, vldl, hdl, and what are the desirable serum lipid levels associated with each. Chylomicrons: triglyceride fat & proteins from food that goes from intestines to liver to muscle to adipose tissue. Ldl (low density lipoproteins): carries fats/cholesterol around the body through the blood to be used by the cells = bad cholesterol: 10% triglycerides, 45% cholesterol, 22% phospholipid, 25% protein. Vldl (very-low density lipoproteins): carries fats/cholesterol from the liver to cells for them to use = bad cholesterol can be changed by some enzymes to become ldl: 55-65% triglycerides, 10-15% cholesterol, 15-20% phospholipid, 5-10% protein. Hdl (high density lipoproteins): carries fats/cholesterol away from the circulation (from the tissues to the liver to be excreted in the bile) = good cholesterol. Abnormally high levels of any or all lipids/lipoproteins in the blood. Total cholesterol = ldl + hdl + (triglycerides/5)
