BIOLOGY 154 Lecture Notes - Lecture 5: Antibody, T Cell, Blood Transfusion
15 Sep 2016
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Examine blood of animals who died of anthrax. Noticed that rods were absent from blood of healthy animals. Wanted to transfer rods to healthy mice to see effect. Transferred blood of animal that died of anthrax with a splinter and mouse died next day. Dead mouse filled with rods, only a few transferred. Created in vitro culture system to watch rods grow and repeated many times. Start with correlation and try identify the agent of causation. Koch"s postulates: pathogen present in all diseased individuals and not present in healthy ones, pathogens can be isolated from host and grown in culture. If inoculate isolated pathogen into a healthy host, then should cause disease: reisolate microbe from experimental infection. Can"t always complete this for all diseases. Some people carry the disease and don"t get sick (breaks postulate #1) Only 30% of people infected with tb develop tuberculosis. Polio virus only causes paralysis in 10% of those infected.
